Matthias Lange Selected Research

Smoke Inhalation Injury

4/2014	No correlation between initial arterial carboxyhemoglobin level and degree of lung injury following ovine burn and smoke inhalation.
11/2012	Administration of a peroxynitrite decomposition catalyst into the bronchial artery attenuates pulmonary dysfunction after smoke inhalation and burn injury in sheep.
12/2011	Direct delivery of low-dose 7-nitroindazole into the bronchial artery attenuates pulmonary pathophysiology after smoke inhalation and burn injury in an ovine model.
6/2011	Beneficial effects of concomitant neuronal and inducible nitric oxide synthase inhibition in ovine burn and inhalation injury.
4/2011	Preclinical evaluation of epinephrine nebulization to reduce airway hyperemia and improve oxygenation after smoke inhalation injury.
2/2011	Beneficial pulmonary effects of a metalloporphyrinic peroxynitrite decomposition catalyst in burn and smoke inhalation injury.
4/2010	A novel bronchial artery catheterization technique with preserved blood flow in an ovine model.
3/2010	Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury.
1/2010	A murine model of sepsis following smoke inhalation injury.
11/2009	Beneficial effect of a hydrogen sulphide donor (sodium sulphide) in an ovine model of burn- and smoke-induced acute lung injury.

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Matthias Lange Research Topics

Disease

25	Sepsis (Septicemia) 12/2013 - 01/2006
19	Acute Lung Injury 12/2012 - 02/2008
18	Septic Shock (Toxic Shock Syndrome) 01/2011 - 11/2006
17	Burns 04/2014 - 02/2008
15	Hypotension (Low Blood Pressure) 04/2011 - 11/2006
14	Smoke Inhalation Injury 04/2014 - 02/2008
12	Endotoxemia 05/2011 - 01/2006
9	Shock 04/2011 - 11/2006
8	Lung Injury 04/2014 - 07/2008
7	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 11/2008 - 11/2006
6	Pulmonary Edema 11/2012 - 01/2009
6	Inflammation (Inflammations) 05/2011 - 11/2006
5	Wounds and Injuries (Trauma) 03/2015 - 07/2009
5	Edema (Dropsy) 12/2011 - 07/2008
5	Airway Obstruction (Choking) 12/2011 - 02/2008
4	Pneumonia (Pneumonitis) 11/2012 - 05/2008
4	Stroke (Strokes) 01/2011 - 11/2007
2	Hepatocellular Carcinoma (Hepatoma) 01/2019 - 10/2016
2	Hypoxia (Hypoxemia) 05/2017 - 10/2007
2	Multiple Trauma (Multiple Injuries) 03/2015 - 04/2011
2	Hyperemia 04/2011 - 07/2009
2	Peritonitis 01/2011 - 10/2010
2	Multiple Organ Failure (MODS) 01/2009 - 10/2007
1	Cicatrix (Scar) 01/2021
1	Neoplasms (Cancer) 01/2019
1	Cyanosis 05/2017
1	Methemoglobinemia 05/2017
1	Seizures (Absence Seizure) 05/2017
1	Liver Neoplasms (Liver Cancer) 10/2016
1	Respiratory Insufficiency (Respiratory Failure) 05/2012
1	Infections 04/2012
1	Bacterial Infections (Bacterial Infection) 01/2012

Drug/Important Bio-Agent (IBA)

19	SmokeIBA 04/2014 - 02/2008
14	Oxygen (Dioxygen)IBA 05/2017 - 01/2006
12	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/2012 - 01/2009
12	CatecholaminesIBA 01/2009 - 01/2006
10	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2011 - 01/2007
8	TerlipressinIBA 05/2011 - 09/2007
8	Saline SolutionIBA 04/2011 - 01/2006
7	salicylhydroxamic acid (SHAM)IBA 04/2014 - 02/2008
7	Nitric Oxide Synthase (NO Synthase)IBA 12/2013 - 01/2009
7	Arginine Vasopressin (Argipressin)IBA 01/2011 - 01/2006
6	Vasopressins (Vasopressin)IBA 05/2011 - 01/2006
5	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 12/2010 - 01/2009
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2012 - 01/2009
4	Proteins (Proteins, Gene)FDA Link 11/2012 - 04/2008
4	Protein Isoforms (Isoforms)IBA 06/2011 - 01/2009
4	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 06/2011 - 01/2009
4	Vasoconstrictor AgentsIBA 07/2009 - 11/2007
4	Adenosine Triphosphate (ATP)IBA 11/2007 - 11/2006
3	Pharmaceutical PreparationsIBA 05/2017 - 01/2007
3	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 12/2012 - 03/2010
3	3-nitrotyrosineIBA 11/2012 - 01/2009
3	Reactive Nitrogen SpeciesIBA 11/2012 - 02/2011
3	Peroxynitrous Acid (Peroxynitrite)IBA 11/2012 - 08/2010
3	Malondialdehyde (Propanedial)IBA 12/2011 - 04/2011
3	NitratesIBA 12/2011 - 11/2008
3	NitritesIBA 12/2011 - 11/2008
3	Poly Adenosine Diphosphate RiboseIBA 06/2011 - 01/2009
3	Peroxidase (Myeloperoxidase)IBA 06/2011 - 11/2009
3	EndotoxinsIBA 04/2011 - 11/2007
3	Dobutamine FDA LinkGeneric 01/2010 - 01/2006
3	Potassium Channels (Potassium Channel)IBA 04/2008 - 10/2007
3	PotassiumIBA 10/2007 - 11/2006
2	Sorafenib (BAY 43-9006)FDA Link 01/2019 - 10/2016
2	Oleanolic AcidIBA 01/2019 - 10/2016
2	CarboxyhemoglobinIBA 04/2014 - 05/2011
2	Interleukin-6 (Interleukin 6)IBA 05/2012 - 01/2012
2	CytokinesIBA 04/2012 - 01/2010
2	Crystalloid SolutionsIBA 04/2011 - 04/2010
2	Simendan (Levosimendan)IBA 10/2010 - 01/2010
2	NitrogenIBA 01/2010 - 12/2009
2	Halothane (Fluothane)FDA Link 01/2009 - 02/2008
2	Vasopressin Receptors (Arginine Vasopressin Receptor)IBA 06/2008 - 05/2008
2	Glyburide (Glibenclamide)FDA LinkGeneric 04/2008 - 11/2007
2	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 04/2008 - 01/2008
2	KATP ChannelsIBA 04/2008 - 10/2007
2	TeaIBA 07/2007 - 12/2006
2	Glipizide (Glucotrol)FDA LinkGeneric 06/2007 - 11/2006
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019
1	Lidocaine (Xylocaine)FDA LinkGeneric 05/2017
1	MethemoglobinIBA 05/2017
1	phytobacteriomycin (PBM)IBA 03/2015
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 12/2012
1	N- (oxo- 5,6- dihydrophenanthridin- 2- yl)- N,N- dimethylacetamide hydrochlorideIBA 12/2012
1	Messenger RNA (mRNA)IBA 11/2012
1	C-Reactive ProteinIBA 01/2012
1	ProcalcitoninIBA 01/2012
1	7-nitroindazoleIBA 12/2011
1	NeuropeptidesIBA 12/2011
1	Adenosine Diphosphate (ADP)IBA 06/2011

Therapy/Procedure

9	Therapeutics 01/2011 - 01/2008
3	Injections 07/2013 - 11/2007
3	Resuscitation 04/2011 - 01/2008
2	Drug Therapy (Chemotherapy) 01/2019 - 10/2016
2	Anesthesia 12/2011 - 01/2009
1	Catheter Ablation 01/2021
1	Continuous Positive Airway Pressure 05/2017
1	Blood Transfusion (Blood Transfusions) 03/2015
1	Microspheres (Microsphere) 07/2013